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It has been well-documented that increased infiltration of immune cells into tumor masses can result in physical destruction of the targeted tumor cells, with a concomitant reduction in tumor burden and improvement in patient prognosis [1-4]. Paradoxically, it is equally well-documented that pre-invasive epithelial tumors with increased immune cell infiltration have a significantly higher frequency of progression to invasive lesions than their stage- and histopathologically-matched counterparts lacking distinct immune cell infiltrates [5-7]. In addition, a number of in vitro studies have suggested that tumor infiltrating immune cells can promote tumor invasion and metastasis through a number of mechanisms [8-12]. Unfortunately, the direct impact of tumor-infiltrating immune cells and the factors that regulate their ability to either inhibit or promote neoplastic progression remain elusive, making it difficult to judge the clinical significance of tumor-infiltrating immune cells.. With further research, a new β-alanine functionalized gadofullerene nanocrystals, (Gd@C82)m(Ala)n, were developed and applied to vascular disruption [33]. Compared with GFNCs, this new nanoparticle presented superior physicochemical properties, which could improve the antitumor effects as vascular disrupting agents. The technique based on RF-assisted functionalized gadofullerene as a new tumor vascular disrupting strategy brings a new dawn for cancer treatment.. Interaction between AGE and RAGE also stimulates and activates nuclear NF-κB that is one of the redox sensitive transcription factors [28]. AGE-RAGE interaction with activated NF-κB pathway controls the expression of various inflammatory cytokines such as TNF-α, IL-1, and PAI-1 [28, 29]. Expression levels of these cytokines are increased in PCOS women compared to those of healthy controls. They have an effect on endothelial dysfunction and vascular injury that can implicated in the pathogenesis of PCOS and infertility [30]. AGE localizes in follicular cell layers except for endothelial cells in ovaries of normal controls. However, in PCOS ovaries, AGE expression is observed in follicular cell layers and endothelial cells. Similar expression of RAGE is detected in follicular, endothelial, and stromal cells in normal ovaries and PCOS ovaries [31]..

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